Michelle Pearson had been in hospital with severe burns to 75 per cent of her body ever since the fire in December 2017
Michelle Pearson had spent '20 months fighting', according to her mother in a post on Facebook.
She lost 15 year old Demi, Brandon who was eight, 7 year old Lacie and Lia who was three.
Detective Superintendent Lewis Hughes, of Greater Manchester Police, said: “Yesterday, we were made aware that Michelle Pearson, who was seriously injured in a house fire in Walkden in 2017, passed away.
“As the Senior Investigating Officer for the investigation into the fire, I know first-hand how devastating the death of her four children was for Michelle and the news of her passing is incredibly tragic.
“I would like to extend my sincere condolences to Michelle’s loved ones at this terrible time. We will ensure that they receive any support they need from the investigation team as they come to terms with their loss.”